Here are Alexander von Humboldt, whose epic explorations of South America surpassed the Lewis and Clark expedition; Harriet Beecher Stowe, “the little woman who made the big war”; Frederic Remington; the extraordinary Louis Agassiz of Harvard; Charles and Anne Lindbergh, and their fellow long-distance pilots Antoine de Saint-Exupéry and Beryl Markham; Harry Caudill, the Kentucky lawyer who awakened the nation to the tragedy of Appalachia; and David Plowden, a present-day photographer of vanishing America. Different as they are from each other, McCullough’s subjects have in common a rare vitality and sense of purpose. These are brave companions: to each other, to David McCullough, and to the reader, for with rare storytelling ability McCullough brings us into the times they knew and their very uncommon lives.

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    While an illness keeps her bedridden, Bailey watches a wild snail that has taken up residence on her nightstand. As a result, she discovers the solace and sense of wonder that this mysterious creature brings and comes to a greater understanding of her own confined place in the world. Intrigued by the snail’s molluscan anatomy, cryptic defenses, clear decision making, hydraulic locomotion, and mysterious courtship activities, Bailey becomes an astute and amused observer, providing a candid and engaging look into the curious life of this underappreciated small animal.  Told with wit and grace, The Sound of a Wild Snail Eating is a remarkable journey of survival and resilience, showing us how a small part of the natural world illuminates our own human existence and provides an appreciation of what it means to be fully alive.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    In The Fractalist, Mandelbrot recounts the high points of his life with exuberance and an eloquent fluency, deepening our understanding of the evolution of his extraordinary mind. We begin with his early years: born in Warsaw in 1924 to a Lithuanian Jewish family, Mandelbrot moved with his family to Paris in the 1930s, where he was mentored by an eminent mathematician uncle. During World War II, as he stayed barely one step ahead of the Nazis until France was liberated, he studied geometry on his own and dreamed of using it to solve fresh, real-world problems. We observe his unusually broad education in Europe, and later at Caltech, Princeton, and MIT. We learn about his thirty-five-year affiliation with IBM’s Thomas J. Watson Research Center and his association with Harvard and Yale. An outsider to mainstream scientific research, he managed to do what others had thought impossible: develop a new geometry that combines revelatory beauty with a radical way of unfolding formerly hidden laws governing utter roughness, turbulence, and chaos. Here is a remarkable story of both the man’s life and his unparalleled contributions to science, mathematics, and the arts.

    When he emerged three years later, the summation of his efforts only hinted at what he'd experienced in one of the most dangerous regions on earth. Armed with an astonishing collection of zoological specimens, Du Chaillu leapt from the physical challenges of the jungle straight into the center of the biggest issues of the time--the evolution debate, racial discourse, the growth of Christian fundamentalism--and helped push each to unprecedented intensities. He experienced instant celebrity, but with that fame came whispers--about his past, his credibility, and his very identity--which would haunt the young man. Grand in scope, immediate in detail, and propulsively readable, Between Man and Beast brilliantly combines Du Chaillu's personal journey with the epic tale of a world hovering on the sharp edge of transformation.

    During her 24-hour shifts at Heathrow, Dr Green had to be ready for anything: from finding an abandoned suitcase leaking blood onto the carousel, to discovering a man smuggling heroin in a corset.It's a job that brought her into contact with all walks of life; her patients included drug mules and fugitives, schizophrenics and stowaways, refugees and tourists. And with the threats of a nerve agent poisoning or a Level Four viral epidemic always in the back of her mind, Dr Green found herself on the frontline where the decisions are made about who - or what - was allowed to leave the airport's borders.FLIGHT RISK reveals the drama that takes place behind-the-scenes of an airport and what is needed to make critical decisions in this hidden no-man's land of geopolitics, terror, tragedy and medicine.

    The fantastic journey began in 1977, before the first episode of Cosmos aired. The mission was planned as a grand tour beyond the moon; beyond Mars, Jupiter, and Saturn; and maybe even into interstellar space. The fact that it actually happened makes this humanity's greatest space mission.In The Interstellar Age, award-winning planetary scientist Jim Bell reveals what drove and continues to drive the members of this extraordinary team, including Ed Stone, Voyager's chief scientist and the one-time head of NASA's Jet Propulsion Lab; Charley Kohlhase, an orbital dynamics engineer who helped to design many of the critical slingshot maneuvers around planets that enabled the Voyagers to travel so far; and the geologist whose Earth-bound experience would prove of little help in interpreting the strange new landscapes revealed in the Voyagers' astoundingly clear images of moons and planets.Speeding through space at a mind-bending eleven miles a second, Voyager 1 is now beyond our solar system's planets. It carries with it artifacts of human civilization. By the time Voyager passes its first star in about 40,000 years, the gold record on the spacecraft, containing various music and images including Chuck Berry's "Johnny B. Goode," will still be playable.

    She'll take you searching for bodies of loved ones - through woodlands, along hedgerows, field-edges, and through plantations - solving time since death, and disposal of remains, from ditches to living rooms. She will give you glimpses of her own history: her loves, her losses, and the narrow little valley in Wales where she first woke up to the wonders of the natural world. Pat will show you how her work with a microscope reveals tell-tale traces of the world around us, and how these have taken suspects of the darkest criminal activities to court.From flowers, fungi, tree trunks to car pedals, walking boots, carpets, and corpses' hair, Traces is a unique book on life, death, and one's indelible link with nature.

    The first epidemic to emerge in the era of climate change, the disease infects half a million people in the US and Europe each year, and untold multitudes in Canada, China, Russia, and Australia. Mary Beth Pfeiffer shows how we have contributed to this growing menace, and how modern medicine has underestimated its danger. She tells the heart-rending stories of families destroyed by a single tick bite, of children disabled, and of one woman’s tragic choice after an exhaustive search for a cure. Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity’s role in a modern scourge.

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    A lifelong friendship and enormously productive collaboration was born, despite sharp differences in personality. The soft-spoken Wheeler, though conservative in appearance, was a raging nonconformist full of wild ideas about the universe. The boisterous Feynman was a cautious physicist who believed only what could be tested. Yet they were complementary spirits. Their collaboration led to a complete rethinking of the nature of time and reality. It enabled Feynman to show how quantum reality is a combination of alternative, contradictory possibilities, and inspired Wheeler to develop his landmark concept of wormholes, portals to the future and past. Together, Feynman and Wheeler made sure that quantum physics would never be the same again.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?"The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception.Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.